NSAIDs and the risk of acute myocardial infarction.
Nat Clin Pract Rheumatol. 2007;3(4):202-3.
ABSTRACT
The overall safety profile of NSAIDs has received much attention. Gastrointestinal complications that are associated with this class of drugs have been known for a long time. Selective COX2 inhibitors, the introduction of which was expected to help avoid the gastrointestinal complications associated with NSAIDs, have now raised new concerns on cardiovascular safety. It has since been discovered that traditional (i.e. nonselective) NSAIDs could also share some of the cardiovascular risks associated with selective COX2 inhibitors. The body of evidence in this regard consists of data from clinical trials and from an increasing number of observational studies, most of which have used patient data from large databases such as the General Practice Research Database in the UK, or administrative databases in the US or Canada.