Gallbladder disease in the general population: association with cardiovascular morbidity and therapy.
Pharmacoepidemiol Drug Saf. 2007;16(5):524-31.
ABSTRACT
Methods: We identified all incident cases of gallbladder disease occurring
during 1996 among patients aged 20-79 years old registered in the General
Practitioner Research Database. We performed a nested case control
analysis using 2,353 cases and 10,000 controls frequency matched to the
cases by age and sex.
Results: After adjusting for potential confounders IHD was associated with
a small increased risk of GB disease (1.29, 95%CI:1.08-1.55). When only
cases requiring cholecystectomy were considered in the analysis, the
resulting estimate was 1.06 (95%CI:0.83-1.35). Users of thiazide diuretics
presented an OR of 1.36 (95%CI:1.08-1.71). Other antihypertensive drugs
were not associated with GB disease.
Conclusions: Our results confirm the small increased risk of GB disease
associated with thiazide diuretics. On the other hand, our data do not
support a major association between IHD and GB disease.
Purpose: Both Gallbladder (GB) and cardiovascular disease are very
common diagnoses that carry substantial economic costs. Prior studies
suggest that personal history of ischaemic heart disease (IHD) could
determine the occurrence of GB disease. Additionally the use of thiazide
diuretics may also be a risk factor for this condition. We aimed to evaluate
different cardiovascular conditions and related drugs that could be
associated with GB disease