Prostate cancer risk among men with diabetes mellitus.
Cancer Causes and Control. 2005;16:1055-1058.
ABSTRACT
Methods: Population based case-control study nested in a cohort.
Results: We identified 2,183 incident cases of prostate cancer between
January 1995 and December 2001. We found that diabetic patients had a
decreased risk of prostate cancer (OR=0.72; 95%CI:0.59-0.87). This
association was observed among treated diabetics (OR=0.63;
95%CI:0.50-0.80) but not among untreated diabetics (OR=1.01;
95%CI:0.73-1.40). Our results suggest that the observed reduced risk
could be restricted to users of insulin or sulphonylureas.
Conclusion: Patients with diabetes have a decreased risk of prostate
cancer. The role of antidiabetic treatment in this association warrants
further research.
Objective: Observational studies have associated diabetes with a
decreased risk of prostate cancer. We aimed to evaluate this association
using the General Practitioner Research Database in the UK.