Breast cancer incidence and use of antihypertensive medication in women.
Pharmacoepidemiology and Drug Safety. 2004;13:581-585.
ABSTRACT
Methods: We performed a cohort study with a nested case-control analysis using the General Practitioner Research Database (GPRD) from the UK. We obtained adjusted estimates by fitting logistic regression models.
Results: The incidence rate of breast cancer in our cohort of women aged 30-79 years was 156 per 100 000 person-years. Overall, incidence of breast cancer among users of antihypertensive drugs was no different from the one among non-users (odds ratio (OR): 1.0; 95% confidence interval (CI): 0.9-1.1). Captopril was not associated with a reduced risk of breast cancer (OR: 0.9; 95%CI: 0.6-1.3).
Conclusions: We did not find any clear association between antihypertensive drugs and risk of breast cancer. Similarly, captopril was not associated with a reduced risk of breast cancer risk.
Purpose: Breast cancer is the most common cancer in women worldwide. We attempted to investigate the association between the risk of breast cancer and use of captopril and other antihypertensive medication.