The incidence of bleeding complications associated with warfarin treatment in general practice in the United Kingdom.
Brit J of Gen Pract 2003;53:312-314
ABSTRACT
The study aim was to estimate and explore the incidence of warfarin related bleeding in a representative sample of UK patients. We identified 3958 patients aged 40-84, newly treated with warfarin and with no prior history of bleeding from the General Practice Research Database and followed them for 12 months. The overall incidence of first-time, idiopathic bleeding was 15.2 per 100 patient-years of current warfarin exposure: the incidence of fatal/hospitalised and referred bleeding was 3.5 and 2.6 per 100 patient-years respectively.